Deleting an iSCSI target removes access to its connected iSCSI logical units. When an iSCSI target is deleted, the iSNS database cannot find the iSCSI targets anymore, thus the iSCSI initiators cannot access the logical units as local hard drives.
Navigate to Configuration > iSCSI > iSCSI Target Domain.
In the iSCSI Targets pane, select the EVS associated with the target from the list of EVS instances.
Select one or more targets that you want to delete, and then click Delete.